Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . The sites of action of several antihyperlipidemic drugs are shown. .. on LDL cholesterol, they are often combined with other antilipidemic drugs for treatment of. Antihyperlipidemic Drugs Dr Ahmed Bader Faculty of Medicine, Menoufiya University, Egypt.

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Views Read Edit View history. Vaxelis Vaxelis is a hexavalent combination vaccine indicated for active immunization Colesevelam Colestilan Colestipol Colestyramine Colextran. But it is not yet known whether antilipdiemic cholesterol-lowering power will translate into a reduced number of heart attacks. Antihyperlipidemic agents What are Antihyperlipidemic agents?

The druge for the treatment of dyslipidemia today comprises six different modes of action with overall around 24 different drugs. The treatment of lipid disorders was revolutionized with the introduction of statins which have become the most important therapeutic option available today to reduce and prevent atherosclerosis and its detrimental consequences like cardiovascular diseases and stroke.

Repatha was approved to treat patients with heterozygous familial hypercholesterolemia HeFH and patients with the rarer homozygous HoFH form of the disease. The product will be available next week. Please enter User Name. Clinically, the choice of an agent will depend on the patient’s cholesterol profilecardiovascular riskand the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications.


Please enter User Name Password Error: Types of Antihyperlipidemic agents Please refer to the drug classes listed below for further information.

HDL participates in pathways that retrieve cholesterol from the artery wall and inhibit the oxidation of atherogenic lipoproteins. Please enter Password Forgot Username? Ultomiris Ultomiris ravulizumab-cwvz is a long-acting C5 complement inhibitor for the About MyAccess If your institution subscribes to this resource, and you don’t have a MyAccess Profile, please contact your library’s reference desk for information on how to gain access to this resource from off-campus.

Lipid-lowering agent

Lipids, mainly cholesterol and triglycerides, are transported in human plasma by macromolecular complexes termed lipoproteins. Anticancer agents Antimetabolites Alkylating Spindle poisons Antineoplastic Topoisomerase inhibitors. The available drugs today for the treatment of dyslipidemia drgus small organic molecules or nonabsorbable polymers for binding of bile acids to be applied orally.

There are several classes of hypolipidemic drugs. Sign in via OpenAthens. In some cases, lowering serum lipid concentrations has been shown to prevent the sequelae of atherosclerosis and decrease mortality in patients with a history of cardiovascular disease and hyperlipidemia.

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This page was last edited on 23 Februaryat Receptor-mediated uptake is a carefully regulated process that protects cells from antilipiddemic overloaded with lipids.

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Home Books Pharmacology for the Physical Therapist. Macrophages in arterial walls use scavenger receptors to take up circulating lipoproteins, especially particles with apolipoproteins that have been modified by free radicals. Amgen said it plans to make the monthly dosing option available next year. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.


Emollients Cicatrizants Antipruritics Antipsoriatics Medicated dressings. In contrast, uptake by scavenger receptors is an unregulated process that can overwhelm the ability of a cell to sequester potentially toxic lipids safely. View All Subscription Options.

List of Antihyperlipidemic agents – Generics Only –

For example, some may lower the “bad cholesterol” low density lipoprotein LDL more so than others, while others may preferentially increase high density lipoprotein HDL”the good cholesterol”.

Always consult your healthcare provider to ensure drubs information displayed on this page applies to your personal circumstances. Whereas plaques can slowly occlude coronary and cerebral vessels, clinical symptoms are more frequently precipitated by rupture of unstable plaques, leading to occlusive thrombi.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Accessed December 31, Besides small anyilipidemic for novel targets, biological drugs such as monoclonal antibodies, antisense or gene-silencing oligonucleotides, peptidomimetics, reconstituted synthetic HDL particles and therapeutic proteins are novel approaches in clinical development are which have antilipidemlc be applied by injection or infusion.

For identification of abbreviations of the lipoproteins, some drug classes, and additional discussion, see text.