Request PDF on ResearchGate | Intérêt des acides biliaires dans la cholestase gravidique | Intrahepatic cholestasis during pregnancy is a risk factor for. La cholestase gravidique a été reliée à des critères de jugement maternels et fœtaux/néonatals indésirables. Du fait que la physiopathologie est mal comprise, . Interventions pour le traitement de la cholestase gravidique. This is not the most recent version of this Review. view the current version 24 June

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Its prevalence in France is of the order of 1 per pregnancies. Access to the full text of this choleetase requires a subscription. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.

The disease is probably due to susceptibility to estrogens and progesterone, whose serum concentration is elevated during pregnancy and which are cholestatic.

Besides disturbing pruritus, maternal prognosis is good. It occurs during the second or third trimester.



Elle survient pendant le 2 e ou le 3 e trimestre de la grossesse. As per cholestasr Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawcholwstase art 34 of that law and rectify art 36 of that law your personal data. If you want to subscribe to this journal, see our rates You can purchase this item in Pay Per View: Top of the page – Article Outline.

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The susceptibility is explained by polymorphisms of genes encoding hepatocytic transport proteins that are important for bile secretion. The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.

It is slightly more frequent during twin pregnancies. Access to the PDF text. Contact Help Who are we?

Clinical signs and biochemical abnormalities normalize rapidly after delivery, at most after 3 to 4 weeks. La cholestase gravidique Intrahepatic cholestasis of pregnancy. Gravity of the disease comes from the occurrence of fetal complications, in particular prematurity rgavidique induced by obstetrical teams and its pulmonary complications, and sudden intra-uterine fetal death.



Liver tests are abnormal, with mainly an increase in serum transaminases and bile acids. Bile acids, Ursodeoxycholic acid, Prematurity, Pruritus. Treatment by the bile acid ursodeoxycholic acid improves pruritus and decreases the frequency of fetal complications, without side effects in the mother or baby.

Journal page Archives Contents list. In forms with severe pruritus, early delivery by induced labor between 37 and 38 weeks may be necessary. Access to the text HTML.

Hépato-Gastro & Oncologie Digestive

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Cholestasis of pregnancy presents with pruritus, sometimes incapacitating, less frequently by jaundice.